https://doi.org/10.4081/mw.2023.1

The neuro-inflammatory perspectives on the application and utilization of ursodeoxycholic acid in schizophrenia

Vol. 1 No. 1 (2023)
Submitted: 2023 August 8
Accepted: 2023 August 10
Published: 2023 August 28
Neuro-inflammation, schizophrenia, ursodeoxycholic acid
Abstract Views: 8860
PDF: 100
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • Mohsen Khosravi • m.khosravi@zaums.ac.ir Department of Psychiatry, School of Medicine, Zahedan University of Medical Sciences; Health Promotion Research Center, Zahedan University of Medical Sciences, Iran, Islamic Republic of.

Various research methods to treat schizophrenia have experienced conflicting etiological theories through their evolution, with diverse emphasis on genetic, physiological, biochemical, and psychological aspects. However, major breakthroughs have not been reached despite decades of research on schizophrenia. This article aims to provide perspectives on research findings and cast light on the potential involvement of bile acid metabolism in schizophrenia and its impacts on the neuro-inflammatory response. These results can be exploited to identify new leads for drug treatment through an enhanced understanding of disease pathophysiology.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Trovão N, Prata J, VonDoellinger O, et al. Peripheral biomarkers for first-episode psychosis - opportunities from the neuroinflammatory hypothesis of schizophrenia. Psychiatry Investig 2019;16:177-84. DOI: https://doi.org/10.30773/pi.2018.12.19.1
Ermakov EA, Mednova IA, Boiko AS, et al. Chemokine dysregulation and neuroinflammation in schizophrenia: a systematic review. Int J Mol Sci 2023;24:2215. DOI: https://doi.org/10.3390/ijms24032215
Najjar S, Pearlman DM. Neuroinflammation and white matter pathology in schizophrenia: systematic review. Schizophr Res 2015;161:102-12. DOI: https://doi.org/10.1016/j.schres.2014.04.041
Qing Y, Wang P, Cui G, et al. Targeted metabolomics reveals aberrant profiles of serum bile acids in patients with schizophrenia. Schizophrenia 2022;8:65. DOI: https://doi.org/10.1038/s41537-022-00273-5
Huang F, Pariante CM, Borsini A. From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders. Brain Behav Immun 2022;99:132-46. DOI: https://doi.org/10.1016/j.bbi.2021.09.021
Huang F. Ursodeoxycholic acid as a potential alternative therapeutic approach for neurodegenerative disorders: effects on cell apoptosis, oxidative stress and inflammation in the brain. Brain Behav Immun Health 2021;18:100348. DOI: https://doi.org/10.1016/j.bbih.2021.100348
Upthegrove R, Khandaker GM. Cytokines, oxidative stress and cellular markers of inflammation in schizophrenia. Curr Top Behav Neurosci 2020;44:49-66. DOI: https://doi.org/10.1007/7854_2018_88
Khosravi M. Ursodeoxycholic acid augmentation in treatment-refractory schizophrenia: a case report. J Med Case Rep 2020;14:137. DOI: https://doi.org/10.1186/s13256-020-02484-9

How to Cite

1.
Khosravi M. The neuro-inflammatory perspectives on the application and utilization of ursodeoxycholic acid in schizophrenia. Mental Wellness [Internet]. 2023 Aug. 28 [cited 2024 Jul. 2];1(1). Available from: https://www.mental-wellness-journal.net/mw/article/view/1
Copyright (c) 2023 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.