Prenatal olanzapine exposure and congenital talipes equinovarus (clubfoot): a case report and review of emerging evidence
Accepted: 2024 July 19
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Recently, concerns have emerged about the potential teratogenic effects of olanzapine, particularly its association with congenital malformations such as congenital talipes equinovarus (clubfoot). Evidence from a large Finnish study, which reported a 2.5-fold increase in musculoskeletal anomalies, as well as various case reports, suggests a significant link between in-utero exposure to olanzapine and these anomalies. This case report aims to add to the growing body of evidence by detailing a new instance of clubfoot following prenatal olanzapine exposure. A 25-year-old woman suffering from bipolar I disorder with psychotic features was treated with olanzapine during pregnancy, resulting in the birth of a male infant with clubfoot but no other malformations. This case underscores the importance of careful risk assessment and monitoring for pregnant women undergoing psychiatric treatment with olanzapine. Potential mechanisms, such as disrupted fetal musculoskeletal development due to olanzapine’s pharmacological effects, warrant further investigation. Comparative analysis with other cases highlights consistent patterns, emphasizing the need for further research to elucidate the mechanisms and risk factors involved.
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